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2 The development of these longer acting alternatives has allowed GLP-1 receptor agonists to become a promising therapeutic option for patients with diabetes

Jumping to higher doses without completing each titration tier dramatically increases gastrointestinal side effects and provides no meaningful benefit in terms of weight loss speed

This is the number that got my attention: in the trial data, patients on oral semaglutide had dramatically higher discontinuation rates the "comparable" weight-loss results you see advertised only held for the small fraction who followed the strict protocol perfectly to the end

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